Obstetric Medicine > Volume 2, Number 1 > Pp. 32-33

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Case reports

Deranged liver function tests in pregnancy: the importance of postnatal follow-up

Sophia Stone MD MRCOG   ^* and Joanna C Girling MA MRCP FRCOG    

^* Department of Obstetrics and Gynaecology, St Mary's Hospital, Portsmouth PO3 6AD, UK; Department of Obstetrics and Gynaecology, West Middlesex University Hospital, Twickenham Road, Isleworth, Middlesex TW7 6AF, London, UK

Correspondence to: Dr Joanna C Girling Email: joanna.girling{at}wmuh.nhs.uk

We report an asymptomatic 40-year-old woman with persistently deranged liver function tests found incidentally in the first trimester of her second pregnancy. No cause was apparent clinically, serologically or with imaging studies until a new finding of hepatomegaly led to a repeat ultrasound scan six weeks following delivery. A mass in the region of the common hepatic duct was confirmed to be a cholangiocarcinoma, with vascular invasion precluding curative surgical resection. This case highlights the need for close vigilance of patients with unexplained and persistently abnormal liver function tests, antenatally and postdelivery.

Key Words: liver function tests • cholangiocarcinoma • pregnancy

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