Obstetric Medicine > Volume 2, Number 3 > Pp. 123-125

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Case reports

Hereditary angioedema and pregnancy: successful management of recurrent and frequent attacks of angioedema with C1-inhibitor concentrate, danazol and tranexamic acid – a case report

D S Milingos ^* , P Madhuvrata ^*, J Dean , A Shetty ^* and D M Campbell ^*

^* Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital; Department of Medical Genetics, Aberdeen Royal Infirmary, Aberdeen, UK

Correspondence to: D S Milingos, Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital, Foresterhill Road, Aberdeen AB25 2ZP, UK Email: dmiligk{at}doctors.org.uk

Hereditary angioedema (HAE) is a rare but potentially life-threatening condition caused by deficiency of C1 esterase inhibitor. It is characterized by subcutaneous swelling in any part of the skin, gastrointestinal and respiratory tracts. We present the case of a pregnant woman with known HAE that deteriorated during pregnancy with frequent attacks that were managed successfully with danazol, tranexamic acid and regular intravenous administration of C1 esterase inhibitor.

Key Words: hereditary angioedema • pregnancy • C1 esterase inhibitor • C1-INH

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