Obstetric Medicine > Volume 2, Number 3 > Pp. 93-99

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Review articles

Sepsis in pregnancy and early goal-directed therapy

Julie Joseph MBBS MRCP FAMS   ^* , Aneeta Sinha BMedSci MBBS MRCP FRCA   , Michael Paech MBBS DRCOG FRCA FANZCA FFPMANZCA FRANZCOG (Hon.) DM    and Barry N J Walters MBBS FRACP FRANZCOG    ^** 

^* Department of Medicine, Tan Tock Seng Hospital; K.K. Women's and Childrens Hospital, Singapore; King Edward Memorial Hospital for Women, Subiaco, Western Australia; School of Medicine and Pharmacology, University of Western Australia, King Edward Memorial Hospital for Women, Subiaco, Western Australia; ^** School of Women's and Infants' Health, University of Western Australia, King Edward Memorial Hospital for Women, Subiaco, Western Australia

Correspondence to: Prof Barry N J Walters Email: banjow{at}iinet.net.au

Sepsis is a major cause of serious morbidity and mortality in pregnant women and their babies. Conventional management has evolved over many years. Improved understanding of the underlying pathophysiology and randomized clinical trials have led to recommendations for the formalization and standardization of the management of severe sepsis in non-pregnant patients. Most of these recommendations are applicable to pregnancy. The Surviving Sepsis Campaign and Early Goal Directed Therapy have relevance to the care of pregnant women with serious infection and are reviewed here.

Key Words: sepsis • pregnancy • early goal-directed therapy

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