Obstetric Medicine > Volume 2, Number 4 > Pp. 154-156

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Original articles

Effect of thyroid peroxidase antibodies on thyroid-stimulating hormone reference limits in a primarily Latina population

Richard H Lee MD   ^* , Carole A Spencer PhD   , Martin N Montoro MD   ^* , Paola Aghajanian MD   ^*, T Murphy Goodwin MD   ^*, Erin A Miller BS   ^*, Ivana Petrovic MS   ^*, Lewis E Braverman MD    and Jorge H Mestman MD   ^* 

^* Department of Obstetrics and Gynecology, Los Angeles County–University of Southern California Medical Center, Los Angeles, CA; Department of Medicine, Boston University Medical Center, Boston, MA; Department of Medicine, Los Angeles County–University of Southern California Medical Center, Los Angeles, CA, USA

Correspondence to: Richard H Lee, 1200 N. State Street, Inpatient tower, 3rd floor, Room C3F105, Los Angeles, CA 90033, USA Email: richarhl{at}usc.edu

The aim of the paper is to determine the prevalence of thyroid peroxidase antibodies (TPOAb) and assess its effect on the thyroid-stimulating hormone (TSH) reference range during pregnancy in a primarily Latina population. Serum samples were collected from healthy pregnant women and non-pregnant controls. TSH reference ranges were calculated when TPOAb-positive patients were either included or excluded. A total of 134 pregnant women and 107 non-pregnant controls were recruited. Positive TPOAb titres were found in 23 (17.2%) of the 134 pregnant women, and in 14 (13.1%) of the 107 non-pregnant controls. When the TPOAb-positive women were included in the TSH analysis, the upper reference limit using two different methods was consistently higher: 0–2.2 fold in the non-pregnant women, 2.01–2.78 fold in the first trimester, 3.18–4.7 fold in the second and 1.05–1.42 fold in the third. The lower TSH reference limit was not affected by the inclusion of TPOAb-positive subjects. In conclusion, inclusion of TPOAb-positive patients results in higher upper reference limits during pregnancy.

Key Words: thyroid • pregnancy • reference • Latina

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