Obstetric Medicine > Volume 1, Number 2 > Pp. 65-71

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The molecular genetics of intrahepatic cholestasis of pregnancy

P H Dixon PhD BSc   and C Williamson MD FRCP   

Maternal and Fetal Disease Group, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK

View larger version (45K): [in this window] [in a new window]   Figure 1 Schematic representation of a hepatocyte showing some of the transporters and receptors discussed in this review. BA, bile acid; NTCP, sodium taurocholate cotransporter polypeptide; MRP, multidrug resistance-associated protein; GSH, reduced glutathione; BSEP, bile salt export pump; MDR3, multidrug resistance protein 3; ABCG5/8, ABC heterodimeric transporter 5/8; FIC1, familial intrahepatic cholestasis 1 protein; FXR, farnesoid-X receptor. MRP3 and 4 are alternative export transporters that can transport bile acids back into the blood. Their role in intrahepatic cholestasis of pregnancy has not yet been examined in detail

 

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